Publications

2026

Uriostegui-Arcos M, Wakefield ZP, Gaydukova S, Garcia Lopez P, Mick ST, Tuncay M, Siggers T, Fiszbein A* (2026) Transcription factors act as splicing regulators. In press at Mol Cell. *corresponding author

Wakefield ZP, Fiszbein A* (2026) SpliceImpactR maps alternative RNA processing events driving protein functional diversity. Nucleic Acids Research 54(15):gkag827. doi:10.1093/nar/gkag827 *corresponding author

Merens HE, Raicu AM, Carroll CL, Kourkoulakos M, Fiszbein A, Churchman LS (2026) SRSF1 regulates polyadenylation site selection independently of and through coordination with U1 snRNP. bioRxiv, doi: https://doi.org/10.64898/2026.04.01.715904

Fiszbein A (2026) Gene regulation using antisense oligonucleotides (ASOs). Patent Application No.: 63/729,102

2025

Fisher RJ, Park K, Lee K, Pinjusic K, Vanasse A, Ennis CS, Farokh P, Ficaro SB, Marto JA, Jiang H, Nam E, Stransky S, Duke-Cohan J, Akinci MA, Geethadevi A, Raabe E, Fiszbein A, Demehri S, Sidoli S, Hicks CW, Keskin DB, Wu CJ, Cole PA, Alani RM (2025) CoREST complex inhibition alters RNA splicing to promote neoantigen expression and enhance tumor immunity. JCI Insight, 11(2):e190287

Stigliano JN, Haberfeld E, Marasco LE, Fiszbein A, Proudfoot NJ, Kornblihtt AR (2025) An SMN2 splicing-correcting antisense oligonucleotide promotes gene looping. bioRxiv, doi: https://doi.org/10.1101/2025.10.10.681673. In press at Mol Cell

Fiszbein A* (2025) Visions of the future of molecular cell biology: Splicing-based personalized therapeutics. Nature Reviews Molecular Cell Biology, 26 735–740 *corresponding author

Calvo-Roitberg E#, Carroll CL#, Venev SV, Kim GY, Mick ST, Dekker J, Fiszbein A*, Pai AA* (2025) mRNA initiation and termination are spatially coordinated.*co-corresponding authors #co-firts authors. Science

Kim GY, Carroll CL, Wakefield ZP, Tuncay M, Fiszbein A* (2025) U1 snRNP regulates alternative promoter activity by inhibiting premature polyadenylation. Mol Cell, 85(10): 1968-1981. Featured on the cover

Murali M, Saquing J, Lu S, Gao Z, Jordan B, Wakefield ZP, Fiszbein A, Cooper DR, Castaldi PJ, Korkin D, Sheynkman G (2025) Biosurfer for systematic tracking of regulatory mechanisms leading to protein isoform diversity. Genome Res. Apr 14;35(4):1012-1024. doi: 10.1101/gr.279317.124

2024

Mick ST, Carroll CL, Uriostegui-Arcos M, Fiszbein A* (2024) Hybrid exons evolved by coupling transcription initiation and splicing at the nucleotide level. Nucleic Acid Research, 53(3):gkae1251. doi: 10.1093/nar/gkae1251

Lu Y, Berenson A, Lane R, Guelin I, Li Z, Yin M, Soto-Ugalde LF, Fiszbein A, Fuxman-Bass JI* (2024) A large-scale cancer-specific protein-DNA interaction network. Life Science Alliance, 16;7(10):e202402641. doi: 10.26508/lsa.202402641

2023

Mick ST, Fiszbein A (2023) evopython: a Python package for feature-focused, comparative genomic data exploration. bioRxiv, doi: https://doi.org/10.1101/2023.09.02.556042 [abstract]

Uriostegui-Arcos M, Mick ST, Shi Z, Rahman R, Fiszbein A (2023) Splicing activates transcription from weak promoters upstream of alternative exons. Nature Communications, 14:3435 [abstract]

2022

Fiszbein A*, McGurk M, Calvo-Roitberg E, Kim GY, Burge CB*, Pai, AA* (2022) Widespread occurrence of hybrid internal-terminal exons in human transcriptomes. Science Advances, 8(3). *corresponding authors [abstract]

PhD and Postdoc publications

Wilson C, Giono LE, Rozés-Salvador V, Fiszbein A, Kornblihtt AR, Cáceres A (2020) The histone methyltransferase G9a controls axonal growth by targeting the RhoA signaling pathway. Cell Reports, 31(6): 107639. [abstract]

Burge CB, Fiszbein A (2020) Splicing-dependent transcriptional gene silencing or activation. Patent App 16/530, 149

Fiszbein A, Krick KS, Begg BE, Burge CB (2019) Exon-mediated activation of transcription starts. Cell, 79(7):1551-1565. [abstract]

Highlighted in:

a. Hoffmann T, Valcarcel J (2019) Splicing calls back. Cell, 79(7):1446-1447. [abs]

b. Willson J (2019) Exons as enhancers. Nat Rev Genet, 21:68-69 [abs]

c. Song Y (2020) New beginnings. Nat Chemical Biology, 16:106 [abs]

Berardino BG, Chertoff M, Gianatiempo O, Alberca CD, Priegue R, Fiszbein A, Long P, Corfas G, Cánepa ET (2019) Exposure to enriched environment rescues anxiety-like behavior and miRNA deregulated expression induced by perinatal malnutrition while altering oligodendrocyte morphology. Neuroscience (19)30178-2. [abstract]

Zalcman G*, Federman N*, Fiszbein A, de la Fuente V, Ameneiro L, Schor IE, Romano A (2019) Sustained CaMKII delta gene expression is specifically required for long-lasting memories in mice. Mol Neurobiol 56(2): 1437-1450. [abstract]

Fiszbein A & Kornblihtt AR (2017) Alternative splicing switches: Important players in cell differentiation. BioEssays 39: 1600157. [abstract]

Fiszbein A & Kornblihtt AR (2016) Histone methylation, alternative splicing and neuronal differentiation. Neurogenesis 3:2326-2133. [abstract]

Fiszbein A, Gomez Acuña LI, Godoy Herz MA, Kornblihtt AR (2016) Interplay between chromatin and splicing. Chapter from the book Chromatin Regulation and Dynamics. Elsevier Science & Technology

Fiszbein A, Giono LE, Quaglino A, Berardino BG, Singaut L, von Bildering C, Schor IE, Steinberg JHE, Rossi M, Pietrasanta LI, Caramelo JJ, Srebrow A, Kornblihtt AR (2016) Alternative splicing of G9a regulates neuronal differentiation. Cell Reports 14:2797–2808. Featured on the cover. [abstract]

Fiszbein A, Schor IE, Kornblihtt AR (2015) Fundamentals of NCAM expression, function and regulation of alternative splicing in neuronal differentiation. Chapter from the book Neural surface antigens - from basic biology toward biomedical applications. Elsevier Science & Technology ISBN: 0128011262

Ramallo M, Morandini L, Alonso F, Birba A, Tubert C, Fiszbein A, Pandolfi M (2014) The endocrine regulation of cichlids social and reproductive behavior through the eyes of the chanchita, Cichlasoma dimerus (Percomorpha; Cichlidae). Journal of Physiology 4; 108:194-202. [abstract]

Schor IE* and Fiszbein A*, Petrillo E, Kornblihtt AR (2013) Intragenic epigenetic changes modulate NCAM alternative splicing upon neuronal differentiation. EMBO Journal 14; 32:2264-74. [abstract]

Gómez Acuña LI, Fiszbein A, Alló M, Schor IE, Kornblihtt AR (2012) Connections between chromatin signatures and splicing. Wiley Interdisciplinary Reviews RNA 16; 4:77-91. [abstract]

Dujardin G, Lafaille C, Petrillo E, Buggiano V, Gómez Acuña LI, Fiszbein A, Godoy Herz MA, Nieto Moreno N, Muñoz MJ, Alló M, Schor IE, Kornblihtt AR (2012) Trasncriptional elongation and alternative splicing. Biochim Biophys Acta 1829:134-40. [abstract]

Fiszbein A, Cánepa M, Vázquez GR, Maggese C, Pandolfi M (2010) Photoperiodic modulation of reproductive physiology and behavior in the cichlid fish Cichlasoma dimerus. Physiology and Behaviour 30; 99:425-32. [abstract]