We study the dynamic determinants of co-transcriptional gene regulation across species, individuals, tissues, and cells

Our lab uses a combination of high-throughput, functional genomics, bioinformatics and molecular approaches to study the co-transcriptional gene regulation of mammalian expression programs.

Recent highlights

mRNA initiation and termination are spatially coordinated

mRNA 5’ end choice directly influences mRNA 3’ ends

U1 snRNP regulates alternative promoter activity by inhibiting premature polyadenylation

Splicing factor U1 snRNP activates downstream promoters

Hybrid exons evolved by coupling transcription initiation and splicing at the nucleotide level

Hybrid exons act as terminal or internal exons in different transcripts

Splicing activates transcription from weak promoters upstream of alternative exons

Splicing-switching ASOs can regulate gene expression in human genes

Widespread occurrence of hybrid internal-terminal exons in human transcriptomes

The HIT index identified thousands of previously misclassified hybrid first-internal and internal-last exons

Splicing of internal exons activates proximal upstream weak promoters

Exon-Mediated Activation of Transcription Starts